| OEFEN | 20/07/2021 | 19:00 | SPE B | FC Flora (Recreatief) | 1 – 1 |
| 29/07/2021 | 19:00 | SPE B | SK Vlezenbeek (Reserven) | AFG |
| 31/07/2021 | 19:30 | Eendracht Hekelgem B (4e Prov.) | SPE B | 1 – 1 |
| 05/08/2021 | 19:00 | SPE B | KHO Huizingen B (4e Prov.) | 2 – 0 |
| 19/08/2021 | 16:00 | SPE B | KVC Terheide B (4e Prov.) | AFG |
| 21/08/2021 | 20:00 | VC Leeuwkens Teralfene B (4e Prov.) | SPE B | AFG |
| 31/08/2021 | 19:00 | SPE B | SK Oetingen (Reserven) | 4 – 2 |
| COMP | 04/09/2021 | 19:00 | Leeuw Brucom B | SPE B | 5 – 0 |
| 11/09/2021 | | | | BYE |
| 18/09/2021 | 19:00 | V. Beersel Drogenbos B | SPE B | 4 – 0 |
| 26/09/2021 | 15:00 | SPE B | KHO Huizingen B | 0 – 1 |
| 02/10/2021 | 20:00 | KV Kester-Gooik B | SPE B | 3 – 3 |
| 10/10/2021 | 15:00 | SPE B | FC Galmaarden B | 1 – 7 |
| 16/10/2021 | 19:30 | KFC Wambeek Ternat B | SPE B | … – … |
| 24/10/2021 | 15:00 | SPE B | VK Borchtlombeek B | … – … |
| 31/10/2021 | 15:00 | FC Dworp | SPE B | … – … |
| 07/11/2021 | 14:30 | SPE B | FC Schepdaal B | … – … |
| 14/11/2021 | 14:00 | KV Zuun B | SPE B | … – … |
| 21/11/2021 | 14:30 | SPE B | FC Herne B | … – … |
| 28/11/2021 | 14:30 | SPE B | KHVC Linkebeek | … – … |
| 04/12/2021 | 19:30 | KFC Rhodienne-De Hoek B | SPE B | … – … |
| 12/12/2021 | 14:30 | SPE B | KFC Avenir Lembeek B | … – … |
| 19/12/2021 | 14:30 | SPE B | Leeuw Brucom B | … – … |
| 16/01/2022 | | | | BYE |
| 23/01/2022 | 14:30 | SPE B | V. Beersel Drogenbos B | … – … |
| 29/01/2022 | 19:00 | KHO Huizingen B | SPE B | … – … |
| 06/02/2022 | 15:00 | SPE B | KV Kester-Gooik B | … – … |
| 12/02/2022 | 19:30 | FC Galmaarden B | SPE B | … – … |
| 20/02/2022 | 15:00 | SPE B | KFC Wambeek Ternat B | … – … |
| 06/03/2022 | 15:00 | VK Borchtlombeek B | SPE B | … – … |
| 13/03/2022 | 15:00 | SPE B | FC Dworp | … – … |
| 19/03/2022 | 19:00 | FC Schepdaal B | SPE B | … – … |
| 27/03/2022 | 15:00 | SPE B | KV Zuun B | … – … |
| 02/04/2022 | 19:00 | FC Herne B | SPE B | … – … |
| 09/04/2022 | 20:00 | KHVC Linkebeek | SPE B | … – … |
| 24/04/2022 | 15:00 | SPE B | KFC Rhodienne-De Hoek B | … – … |
| 01/05/2022 | 15:00 | KFC Avenir Lembeek B | SPE B | … – … |
