| OEFEN | 20/07/2021 | 20:00 | FC Galmaarden B (4e Prov.) | SPE A | 1 – 4 |
| OEFEN | 29/07/2021 | 19:30 | SK Vlezenbeek (3e Prov.) | SPE A | 4 – 2 |
| OEFEN | 05/08/2021 | 19:30 | SK Aaigem (3e Prov.) | SPE A | 1 – 2 |
| BEKER | 08/08/2021 | 16:00 | SPE A | Verbroedering Hofstade (4e Prov.) | 5 – 2 |
| OEFEN | 12/08/2021 | 19:30 | SPE A | KFC Lennik (Reserven) | 2 – 2 |
| BEKER | 15/08/2021 | 16:00 | KFC Wezembeek-Oppem (4e Prov.) | SPE A | 0 – 5 (F) |
| OEFEN | 19/08/2021 | 20:00 | FC Schepdaal (2e Prov.) | SPE A | 2 – 2 |
| BEKER | 22/08/2021 | 16:00 | SPE A | Foot Fun Family Brussels (4e Prov.) | 3 – 0 |
| OEFEN | 26/08/2021 | 19:30 | SPE A | VC Groot Dilbeek B (4e Prov.) | 1 – 2 |
| BEKER | 29/08/2021 | 16:00 | Sporting Kortenberg (4e Prov.) | SPE A | 5 – 1 |
| COMP | 05/09/2021 | 15:00 | SPE A | Eendracht Hekelgem | 1 – 1 |
| 12/09/2021 | 15:00 | FC Negenmanneke | SPE A | 1 – 2 |
| 19/09/2021 | 15:00 | SPE A | Toekomst Relegem | 1 – 3 |
| 26/09/2021 | 15:00 | KV Zuun | SPE A | 2 – 1 |
| 03/10/2021 | 15:00 | SPE A | SK Pepingen-Halle B | 6 – 3 |
| 10/10/2021 | 15:00 | KVC Asse-Terheide | SPE A | 2 – 4 |
| 17/10/2021 | 15:00 | SPE A | Ritterklub Jette | … – … |
| 24/10/2021 | 15:00 | KVC Itna Itterbeek | SPE A | … – … |
| 31/10/2021 | 15:00 | SPE A | VK Borchtlombeek | … – … |
| 07/11/2021 | 14:30 | SK Oetingen | SPE A | … – … |
| 14/11/2021 | 14:30 | SPE A | V. Beersel Drogenbos | … – … |
| 21/11/2021 | 14:30 | SK Vlezenbeek | SPE A | … – … |
| 27/11/2021 | 19:30 | KFC MZ Tollembeek | SPE A | … – … |
| 05/12/2021 | 14:30 | SPE A | SV Kobbegem | … – … |
| 12/12/2021 | 14:30 | KFC Avenir Lembeek | SPE A | … – … |
| 18/12/2021 | 20:00 | Eendracht Hekelgem | SPE A | … – … |
| 16/01/2022 | 14:30 | SPE A | FC Negenmanneke | … – … |
| 23/01/2022 | 14:30 | Toekomst Relegem | SPE A | … – … |
| 30/01/2022 | 14:30 | SPE A | KV Zuun | … – … |
| 05/02/2022 | 19:30 | SK Pepingen-Halle B | SPE A | … – … |
| 13/02/2022 | 15:00 | SPE A | KVC Asse-Terheide | … – … |
| 19/02/2022 | 20:00 | Ritterklub Jette | SPE A | … – … |
| 06/03/2022 | 15:00 | SPE A | KVC Itna Itterbeek | … – … |
| 13/03/2022 | 15:00 | VK Borchtlombeek | SPE A | … – … |
| 20/03/2022 | 15:00 | SPE A | SK Oetingen | … – … |
| 27/03/2022 | 15:00 | V. Beersel Drogenbos | SPE A | … – … |
| 03/04/2022 | 15:00 | SPE A | SK Vlezenbeek | … – … |
| 10/04/2022 | 15:00 | SPE A | KFC MZ Tollembeek | … – … |
| 24/04/2022 | 15:00 | SV Kobbegem | SPE A | … – … |
| 01/05/2022 | 15:00 | SPE A | KFC Avenir Lembeek | … – … |
